Research progress of mitotic arrest deficient gene abnormalities in tumor
10.3969/j.issn.1002-3070.2014.02.016
- VernacularTitle:有丝分裂阻滞缺陷基因异常在肿瘤中的研究进展
- Author:
Qian SUN
;
Xianyu ZHANG
;
Da PANG
- Publication Type:Journal Article
- Keywords:
Spindle assembly checkpoint ( SAC);
Mitotic arrest defective ( Mad);
Cancer;
Chemotherapy
- From:
Practical Oncology Journal
2014;(2):170-172
- CountryChina
- Language:Chinese
-
Abstract:
The spindle assembly checkpoint ( SAC) is an important monitoring mechanism to monitor the connection between centromeres and microtubules and to ensure proper chromosome separation in human .Mitotic arrest defective protein(Mad)family,as an important part of SAC,plays a crucial role in the process of mitosis. Mutations or altered expressions of Mad may lead to abnormal separations of chromosomes and play a partial role in tumorigenesis ,poor prognosis and chemotherapy drug resistance .
