Detection and significance ofC D4 +/CD 8 +T cells ratio and TGF-β,IL-4,IL-6 levels in lung cancer patients during perioperative peir od
10.3969/j.issn.1002-3070.2014.03.001
- VernacularTitle:围术期肺癌患者 CD4＋／CD8＋T 细胞与TGF -β、IL -4、IL -6的检测及临床意义
- Author:
Jiasheng HAN
;
Huaxign WU
;
Dexin MENG
;
Aijun XU
;
Rui MENG
- Publication Type:Journal Article
- Keywords:
Lung cancer;
Cytokine;
Immune function
- From:Practical Oncology Journal
2014;(3):193-197
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the changes of CD4 +/CD8 +T cells ratio and TGF -β,IL-4,IL-6 levels in lung cancer patients during the perioperative period and to analyze the clinical significance .Methods Flow cytometer and Elisa were used to analyze the CD 4 +/CD8 +T cells ratio and TGF-β,IL-4,IL-6 levels in peripheral blood sapmles from 20 patients with lung cancer during the perioperative period and 10 healthy con-trolsR. esults Before operation ,the ratios of CD4 +T and CD8 +T cells from 20 patients with lung cancer were (46.26 ±4.26)%and(43.15 ±5.18)%, respectively.On the fifth day after operation ,the ratios of CD4 +T and CD8 +T cells were(44.30 ±4.25)%and(39.80 ±2.53)%.TGF-β,IL-4 and IL-6 levels in 20lung cancer patients were(240.51 ±46.37)pg/mL,(19.85 ±2.52)pg/mL,and(129.28 ±33.06)pg/mL,respectively.On the fifth day after operation,TGF-β,IL-4 and IL-6 levels were(210.79 ±36.94)pg/mL,(17.37 ±2.57) pg/mL,and(107.28 ±27.83) pg/mL.The differences of above parameters between the preoperative period and the fifth day after operation were statistically significant ( P<0.05) . Conclusion The immune suppression oc-curs before its recovery during perioperative period ,the changes of CD4 +/CD8 +T cells ratio and TGF-β,IL-4 and IL-6 levels have significance on monitoring the progress and prognosis of patients with tumor .
