Systematic reviews in the telomerase activity testing for screening lung cancer by use of SROC curve method
10.3969/j.issn.1002-3070.2014.03.004
- VernacularTitle:采用 SROC 曲线法系统评价端粒酶检测筛查肺癌的效果
- Author:
Yunfeng HAN
;
Zhiping XIE
;
Haiying FENG
;
Yongqiang QIU
- Publication Type:Journal Article
- Keywords:
SROC;
Telomerase;
Lung cancer
- From:
Practical Oncology Journal
2014;(3):207-212
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical significance of telomerase in the diagnosis of lung cancerusing SROC curve method.Methods Looking“telomerase”and“lung cancer”as keywords,retrieving journalspublished within past 20 years in order to incorporate into literatures and to collect data .To conduct the SROC analysisusing Meta -DiSc 1.4 software.Results 1.Twenty -two documents were sampled as tissue specimensand the heterogeneity was relatively large (P =0.017).To analyze the data with random effective models ,thecombined sensitivity and specificity were 0.788(0.761 -0.814)and 0.955(0.936 -0.969),respectively.TheSROC AUC area under the curve was 0.9515,SE(AUC) =0.0145.2.There was no heterogeneity(P =0.633)amongthe 10 lavaged literatures.By use of fixed effects model for data analysis ,the combined sensitivity and specificitywere 0.777(0.734 -0.816) and 0.922(0.888 -0.948),and SROC AUC area under the curve was0.9369,SE(AUC) =0.0141.Conclusion Telomerase is a ideal tumor marker,and the detection of telomeraseactivity in lavage fluid is stable and accurate in clinical diagnosis .
