Preliminary exploration of NIR heptamethine complex dyes PZ-1009 in ovarian cancer imaging

VernacularTitle:近红外七甲川菁染料复合物 PZ -1009在卵巢癌成像的初步探索
Author: Lianshan ZHAN ; Gengbiao YUAN ; Dongfeng PAN ; Yuanyi ZHENG ; Yongzeng FAN ; Haitao RAN
Publication Type:Journal Article
Keywords: Cancer; Near infrared fluorescence; Organic dyes; Targeting
From: Practical Oncology Journal 2014;(3):223-227
CountryChina
Language:Chinese
Abstract: Objective To assess the applicative value of near infrared fluorescence compound PZ -1009 in tumor imaging .Methods Near infrared fluorescence imaging properties of the compound was evaluated in a mouse model of ovarian cancer .The athymic nude mice were inoculated with SKOV -3 ovarian cancer cells and imaged in vivo and ex vivo after injecting PZ -1009 and were performed periodically .Results The tumor loca-tion was clearly imaged after 1 h of injection.The maximum fluorescence intensity was at 6 h time point and there was still a few fluorescent signal in tumors after 48hrs.A professional software was used to measure the intensity including all tumors and normal regions .The results showed that the intensity of tumors was higher than all normal regions in any time points .Conclusion The compound of PZ -1009 can efficiently target tumor sites and has great potential in noninvasive real time early tumor diagnosis .