The research development of PI3K/AKT/mTOR signaling pathway in Her-2 resistance for the treat-ment of breast cancer
10.11904/j.issn.1002-3070.2014.04.015
- VernacularTitle:PI3 K／AKT／mTOR 信号通路在乳腺癌 Her -2治疗耐药中的作用研究进展
- Author:
Ruijin MA
;
Yu YANG
- Publication Type:Journal Article
- Keywords:
PI3K/AKT/mTOR pathway;
Her-2;
Breast neoplasms;
Targeted therapy
- From:
Practical Oncology Journal
2014;(4):360-363
- CountryChina
- Language:Chinese
-
Abstract:
Her-2 targeting therapy is an important part of the treatment for breast cancer with Her -2 overexpression.However,the therapeutic effectiveness is largely influenced by Her -2 resistance.Previous studies have confirmed that PI3K/AKT/mTOR signaling pathway is activated during the process of drug resistance to Her-2-targeting therapy.Therefore,investigating the PI3K/AKT/mTOR signaling pathway and drugs -targeted pathway are important for the treatment of breast cancer .
