Effects of altered metabolic enzymes on epigenetic status in gliomas
10.11904/j.issn.1002-3070.2014.04.018
- VernacularTitle:脑胶质瘤代谢酶改变对表观遗传状态的影响
- Author:
Xueping XIANG
;
Yinghui TONG
- Publication Type:Journal Article
- Keywords:
Gliomas;
Metabolic enzymes;
Epigenetic
- From:
Practical Oncology Journal
2014;(4):371-376
- CountryChina
- Language:Chinese
-
Abstract:
Alteration of metabolism and epigenetic status are two new focuses in the field of cancer re -search.Recently,more and more reports have demonstrated that the changes of both metabolic enzymes and al -tered epigenetic status have close interrelationship with the pathogenesis and development of gliomas in human . We discuss here the effects of altered metabolic enzymes on epigenetic status in gliomas based on two important altered metabolic enzymes ,with the aim to unlock the molecular mechanism on how gliomas occur and progress . This newfound molecular mechanism of how altered metabolic enzymes impact on epigenetic status in gliomas may contribute to the identification of novel therapeutic targets to gliomas in the future .
