The research progress of Sox2 gene in malignant tumor
10.3969/j.issn.1002-3070.2014.02.017
- VernacularTitle:恶性肿瘤中 SOX2基因的研究进展
- Author:
Yang TENG
;
Gongyan CHEN
- Publication Type:Journal Article
- Keywords:
Sox2;
Over expression;
Malignant tumor
- From:
Practical Oncology Journal
2014;(2):173-176
- CountryChina
- Language:Chinese
-
Abstract:
Sox2 is one of the important members of the Soxfamily ,It plays an import role in the regulation of early embryo and normal tissue development ,maintain the versatility of stem cells and progenitor cells self -re-newal ability and decide cell fate ,etc.Sox2 genetic mutation or missing may lead to dysplasia or congenital disea-ses.Previous studies showed that Sox 2 expressed in a variety of malignant tumors ,and associated with the inci-dence of malignant tumor ,lymph node metastasis and pathological grading and clinical staging .There fone Sox2 is considered as a potential carcinogenic factor ,its over expression may form one of development of mechanisms for the occurrence and different kinds of malignant tumor .
