Negative expression of RECK indicates unfavorable clinical outcome for breast cancer
10.3969/j.issn.1002-3070.2014.01.003
- VernacularTitle:RECK 蛋白低表达示乳腺癌预后不良
- Author:
Shaoqiang CHENG
;
Yang LIU
;
Xiaoshuan ILANG
;
Da PANG
;
Guoqiang ZHANG
;
Jinsong WANG
;
Yanni SONG
- Publication Type:Journal Article
- Keywords:
Breast cancer;
RECK;
Prognosis
- From:
Practical Oncology Journal
2014;(1):12-18
- CountryChina
- Language:Chinese
-
Abstract:
Objecive To explore the significance of RECK expression in breast cancer .Methods Im-munohistochemical staining was used to analyze RECK expression levels in patients with breast cancer .We com-pared these data with the clinicopathological features of these patients .Rseults Breast cancer patients with nega-tive RECK expression had significantly lower DFS and 5-year survival rates than patients with positive RECK expression.In addition,for node-negative breast cancer ,negative RECK expression indicated markedly unfavor -able survival rate than positive arm .Multivariate analysis further confirmed that RECK expression was an inde -pendent prognostic factor for patients with breast cancer .Conclusion The loss of RECK expression indicates un-favorable survival rate for patients with breast cancer .RECK expression is a new ,important risk factor for recur-rence in breast cancer .
