Analysis of Treg in bone marrow of patients with multiple myeloma and its correlation with clinical prog-nostic factors
10.3969/j.issn.1002-3070.2014.01.011
- VernacularTitle:多发性骨髓瘤患者骨髓中 Treg 细胞与预后相关性研究
- Author:
Xiuchen GUO
;
Lina QUAN
;
Hong LI
;
Lianqiao LI
;
Weiyuan GUO
;
Chuiming JIA
- Publication Type:Journal Article
- Keywords:
Multiple myeloma;
Bone marrow microenvironment;
Treg cells
- From:Practical Oncology Journal
2014;(1):54-58
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate immune function of patients with multiple myeloma ( MM) by detect the changes of the Treg cells in bone marrow of patients with MM .Methods Treg cells in peripheral blood and bone marrow of 45 patients with MM and 15 healthy controls were measured by flow cytometry .Results The per-centage of Treg cells in peripheral blood of MM was higher than that in healthy person ;The percentage of Treg cells in MM bone marrow was lower than that in healthy person ,and the extent was positively correlated with the level of β2-MG and ISS(P<0.05).Conclusion MM Patients display an abnormal level of CD 4 +CD25 +Treg cells,which may be an important mechanism of MM immune deficiency .
