Study on the association between expression and clinicopathological significance of AEG-1 and MMP-9 in colorectal tissue
10.11904/j.issn.1002-3070.2015.03.002
- VernacularTitle:AEG －1、MMP －9在结直肠组织中的表达及临床病理相关性的研究
- Author:
Hongtao SONG
;
Yu QIN
;
Cong LI
;
Guodong YAO
;
Shuhuai WANG
;
Jingshu GENG
- Publication Type:Journal Article
- Keywords:
Astrocyte elevated gene -1;
Matrix metalloproteinase -9;
Colorectal carcinoma;
Colorectal adenoma
- From:
Practical Oncology Journal
2015;(3):197-202
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of astrocyte elevated gene -1( AEG-1) and matrix metallopeptidase 9(MMP-9)in colorectal tissues and evaluate its correlation with clinical pathologic factors of colorectal cancer.Methods AEG-1 and MMP-9 expression in normal colorectal mucous (n=45),low-grade adenoma(n=31),high-grade adenoma(n=15)and colorectal carcinoma(n=146)were examined by immuno-histochemistry .Statistical analyses were applied to test the significance of its expression .Results AEG-1 ex-pression levels were gradually elevated in normal tissues ,low-grade adenoma ,high-grade adenoma and colorec-tal carcinoma respectively .Furthermore ,there was a similar trend for MMP -9from normal mucous to adenoma and carcinoma .Statistical analysis revealed that AEG -1 expression was markedly correlated with the UICC stage,T classification,N classification,M classification,and histological differentiation in the colorectal cancer pa-tients,but not with age,gender,tumor location and tumor size.In addition,AEG-1 expression was positively cor-related with the MMP-9 expression in colorectal cancer .Besides,those patients with high AEG-1 and MMP-9 levels had shorter survival time ( P<0 .05 ) .Conclusion AEG-1 may be involved in carcinogenesis and pro-gression of colorectal carcinoma and can be a novel prognostic biomarker in patients with colorectal carcinoma .
