The advance of Nampt in gliomas
10.3969/j.issn.1002-3070.2014.01.019
- VernacularTitle:Nampt 在胶质瘤中的研究进展
- Author:
Huan SUN
;
Kai ZHANG
;
Wenbing AI
- Publication Type:Journal Article
- Keywords:
Nampt;
Glioma;
Cancer therapy
- From:
Practical Oncology Journal
2014;(1):89-92
- CountryChina
- Language:Chinese
-
Abstract:
Nampt is a rate -limiting enzyme in the mammalian salvaging pathway for the synthesis of NAD that is involved in cell metabolism and proliferation .In recent years,growing research has elucidated that Nampt is correlated to various malignant tumors .It has a complex functions including regulation of energy metabo-lism and genome instability,promotion of proliferation and angiogenesis ,tumor-promoting inflammation and a-voidance of immune destruction .Recent reports indicate that Nampt is highly expressed in gliomas ,and it is close-ly related to the proliferation ,migration,invasion and prognosis of gliomas ,which will provide a new target for the glioma research and therapy .
