The efficacy and safety of HCPT combined with 5-fluorouracil in treatment of bladder cancer
10.11904/j.issn.1002-3070.2016.04.003
- VernacularTitle:羟基喜树碱联合5－氟尿嘧啶于膀胱癌化疗中的疗效及安全性研究
- Author:
Liping LUO
;
Zhenqi WU
- Publication Type:Journal Article
- Keywords:
HCPT;
5-Fu;
Bladder cancer;
Intravesical instillation of chemotherapy;
Safety
- From:
Practical Oncology Journal
2016;30(4):300-303
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy and safety of HCPT combined with 5-fluorouracil(5-Fu) in treatment of bladder cancer .Methods Selected 92 patients with advanced bladder cancer in our hospi-tal from February 2011 to August 2015 , equally divided into observation group and control group of 46 patients based on the random number table ,the control group were received 5-Fu intravesical chemotherapy ,The obser-vation group were given the HCPT combined with 5-Fu chemotherapy ,the chemotherapy infusion were once a week,continuous perfusion were observed for 3 months.Results The response rates in the observation group was 95.7%and the control group was 76.1%,the observation group were significantly higher than the control group (P<0.05).The occurrence of bladder irritation adverse reaction ,blood abnormalities,liver and kidney dysfunc-tion,bone marrow suppression in the observation group during chemotherapy compared with the control group were no significant difference(P>0.05),all adverse reactions after symptomatic treatment were improved .All patients were followed up for 1 year,The mortality and recurrence rates in the observation group were 8.7%and 4.3%re-spectively,while the control group were 30.4%and 17.4%,the mortality and recurrence rates of the observation group were significantly lower than the control group (P<0.05).Conclusion HCPT combined with 5 -Fu chemotherapy for bladder cancer has strong anti -cancer effect and without increase the incidence of adverse re-actions,it can promote the improvement of the long -term prognosis,so it is a safe and effective topical bladder chemotherapy drugs .
