The effects of anti-cancer drug NSC319726 on the gene expression of ovarian cancer
10.11904/j.issn.1002-3070.2016.04.009
- VernacularTitle:抗癌新药NSC319726对卵巢癌基因表达影响的研究
- Author:
Yanhong DENG
;
Xiu LE
;
Wenchao GAO
- Publication Type:Journal Article
- Keywords:
NSC319726;
Ovarian cancer;
Bioinformatic analysis;
GO analysis;
MMP signaling pathway
- From:Practical Oncology Journal
2016;30(4):332-338
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effects of anti -cancer drug NSC319726 on the gene expression of ovarian cancer.Methods The data that NSC319726 acted on the ovarian cancer cell lines TOV112D was down-loaded from the GEO database and then the bioinformatical analysis was conducted .Results NSC319726 in-creased 246 genes including MMP3,CXCR4 et al and decreased 198 genes such as PBX1 in ovarian cancer cell lines.GO analysis indicated that six GO items were related to metabolism .Pathway analysis revealed that NSC319726 could affect the circadian clock and MMP signaling pathway .Conclusion NSC319726 could affect the expression of multiple functional genes in ovarian cancer cell lines and might be a potential drug targeting to the precursor-B cell acute lymphoblastic leukemia .Meanwhile , it should be noted that NSC 319726 may have effects on the tumor metastasis and human sleep .Therefore,further research needs to be conducted before the clinical use .
