NQO1 overexpression is associated with poor prognosis in the uterine cervix carcinoma
10.11904/j.issn.1002-3070.2016.04.012
- VernacularTitle:NQO1高表达提示宫颈癌预后不良
- Author:
Lichun HOU
;
Lijuan LIN
- Publication Type:Journal Article
- Keywords:
Uterine cervix carcinoma;
NQO1;
Human papillomavirus;
Survival analysis
- From:
Practical Oncology Journal
2016;30(4):351-355
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the clinicopathological significance of upregulated NQO 1 protein expression in uterine cervix carcinoma ( UCC) .Methods Immunohistochemical staining was performed on paraf-fin-embedded UCC specimens from 123 patients.Disease-free survival(DFS)and overall survival(OS)rates for all cervical UCC patients were calculated using the Kaplan -Meier method ,and univariate or multivariate analyses were performed using the Cox proportional hazards regression model .Results The NQO1 protein showed a main-ly cytoplasmic staining pattern in cervical cancer cells ,and the strongly positive rate of NQO 1 was significantly higher in UCC.High-level NQO1 was closely associated with poor differentiation ,late-stage,lymph node metas-tasis and high-risk for HPV infection.Additionally,high-level NQO1 was associated with lower DFS and OS rates .Furthermore ,Cox analysis revealed that NQO 1 expression emerged as a significant independent hazard factor for DFS rate in patients with UCC .Conclusion NQO1 overexpression might be an independent biomarker for prognostic evaluation of UCCs .
