Effect and safety of celiac continued circulatory hyperthermia perfusion with chemotherapy in the treat-ment of cancer with ascites Meta-analysis
10.11904/j.issn.1002-3070.2016.04.013
- VernacularTitle:化疗联合腹腔循环热灌注治疗恶性腹水疗效和安全性的Meta分析
- Author:
Xiangyong YAN
;
Zhongsheng YAN
;
Wenchao LIU
;
Hui DING
- Publication Type:Journal Article
- Keywords:
Malignant ascites;
Chemotherapy;
Celiac continued circulatory hyperthermia perfusion;
Meta-analysis
- From:
Practical Oncology Journal
2016;30(4):356-364
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the clinical efficacy and safety of celiac continued circulatory hyper -thermia perfusion with chemotherapy in the treatment of cancer with ascites .Methods Databases including the Cochrane Library MEDLINE,PubMed,Embase,CBM,VIP,CNKI and WanFang Data,and the other sources as supplying .The literatures were screened according to the inclusion criteria ,extracted data and assessed the meth-odological quality ,and then meta -analysis was performed using RevMan 5.0.2 software.Results Totally 14 RCTs with 867 patients were included .Meta-analysis showed that compared intraperitoneal chemotherapy ,with celiac continued circulatory hyperthermia perfusion had a significant difference in CR ( OR=3.18,95%CI:2.18~4.64,P<0.00001),PR(OR=2.05,95%CI:1.51~2.77,P<0.00001),overall effective rate(OR=4.88, 95%CI:3.59~6.46,P<0.00001).The incidence of adverse reactions was no statistically significant in the two groups.Conclusion Celiac continued circulatory hyperthermia perfusion with chemotherapy in the treatment of cancer with ascites demonstrates better efficacy and safety ,but it still needs to verify the above conclusion .
