Clinicalsignificance of Vimentin expression in pati ents with colorectal cancer
10.11904/j.issn.1002-3070.2015.04.007
- VernacularTitle:结直肠癌病人 Vimentin 表达的临床意义
- Author:
Zhaohua GAO
;
Hao ZHANG
;
Gang SHI
- Publication Type:Journal Article
- Keywords:
Vimentin;
Colorectal cancer;
Epithelial-mesenchymal transition(EMT);
Prognosis
- From:
Practical Oncology Journal
2015;(4):319-326
- CountryChina
- Language:Chinese
-
Abstract:
Objective Vimentin is the major protein consisting of intermediate filaments in normal and neoplastic mesenchymal cells.It has been regarded as a marker of epithelial mesenchymal transition( EMT) .How-ever,little is known about colorectal cancer( CRC) with Vimentin expression as a marker of EMT and prognosis. Methods We investigated the expression of Vimentin in CRC tissues and determined the correlations between Vimentin expression patterns and clinicopathologic characteristics and prognosis in CRC.In total,189 patients di-agnosed with CRC based on histopathological evaluation and those subjected to surgical resection at the Liaoning Province Cancer Hospital and Institute between 2000 and 2002 were examined.Immunohistochemical staining for Vimentin was performed for each specimen.Results Positive expression of Vimentin was significantly associated with the lymph node metastasis(pN stage,P=0.038),TNM stage(P=0.024).Survival analysis revealed that positive Vimentin expression was significantly related to poor prognosis ( P =0.016 ) .Multivariate analysis re-vealed that Vimentin expression was an independent prognostic factor for patient survival in colorectal cancer ( P=0.026) .Conclusion In conclusion,our data provide novel evidence for the clinical significance of Vimentin ex -pression as potential predictive biomarkers for identifying patients with lymph node metastasis or poor prognosis in CRC.
