Research progress of the relationship between microRNA and NF-κB in the invasion and metastasis of gastric cancer
10.11904/j.issn.1002-3070.2016.04.017
- VernacularTitle:MicroRNA和NF－κB与胃癌侵袭转移关系的研究进展
- Author:
Jing XIE
;
Tianjiao WANG
;
Xvfeng ZHANG
;
Jin WU
- Publication Type:Journal Article
- Keywords:
Gastric cancer;
MicroRNA;
NF-κB
- From:
Practical Oncology Journal
2016;30(4):380-384
- CountryChina
- Language:Chinese
-
Abstract:
MiRNA is a class of small endogenous non -coding molecule RNA with regulatory functions , which regulates the target genes at the post -transcriptional level by binding with 3′untranslated regions (3′UTR) specifically.Nuclear factor kappaB(NF-κB)is a kind of significant intranuclear transcription factor .Being activ-ized,it easily combines with the fixed nucleotide sequence in promoter region to initiate gene transcription and participates in the invasion and metastasis of gastric cancer .Recent researches showed that miRNA not only influ-ences on tumor invasion and metastasis by regulating the expression of downstream target gene NF -κB,and itself also could be regulated by NF -κB transcription factors .This essay mainly narrates the expression of microRNA and NF-κB in gastric carcinoma ,and summarize the influence to the invasion and metastasis of gastric cancer cells by regulating thier expression interction .
