Research progress and development direction on histological classification system of breast cancer
10.3969/j.issn.1002-3070.2014.02.014
- VernacularTitle:乳腺癌组织学分级系统的研究进展和发展方向
- Author:
Linwei WANG
;
Jingping YUAN
;
Yan LI
- Publication Type:Journal Article
- Keywords:
Breast cancer;
Histological classification system;
Nottingham classification system
- From:
Practical Oncology Journal
2014;(2):160-164
- CountryChina
- Language:Chinese
-
Abstract:
Histological classification system ( HCS) is an important system in judging and predicting ma-lignant behaviors of breast cancer .This study is aimed to analyze research progress and development direction of HCS by perusing literatures ,including the origin and development progress of HCS ,contents and deficiencies of Nottingham classification system(NCS),and introduction of novel classification system .HCS of breast cancer has a history of more than one hundred years ,among which NCS is the most widely used ,based on morphological fea-tures of cancer cells .However,there are still some shortcomings about NCS ,such as few indexes incorporation , great evaluation variation and low evaluation efficiency .Recently ,many newly evaluation systems have been devel-oped,including“nucleus+proliferation”classification system ,computer assisted classification system and compre-hensive prognostic classification model .Therefore,the future development directions of HCS on breast cancer is to use high throughput analysis technology to extract and analyze the hidden molecular information in cancer cells and the surrounding tumor microenvironment ,so as to better guide personalized therapy and predict clinical prog-nosis.
