Epigenomic analysis reveals 23 breast cancer pathogenic genes induced by aberrant DNA methylation
10.11904/j.issn.1002-3070.2015.04.003
- VernacularTitle:表观基因组研究揭示23个由 DNA 甲基化异常介导的乳腺癌致病基因的研究
- Author:
Xiaojuan LIU
;
Wenjie CHEN
;
Hongbo LIU
;
Jinming ZHANG
;
Yan ZHANG
- Publication Type:Journal Article
- Keywords:
Breast cancer;
DNA methylation;
Differentially expressed gene
- From:Practical Oncology Journal
2015;(4):299-304
- CountryChina
- Language:Chinese
-
Abstract:
Objective To identify and analyze the DNA methylation induced pathogenic genes in breast cancer.Methods Using genomic data provided by the international cancer genome,we carried out systematic a-nalysis of the abnormal gene expression in breast cancer and epigenetic regulation mechanism by bioinformatics methods.Results We identified 428 genes with abnormal expressions in breast cancer by t test.Functional enrich-ment analysis revealed genes up-regulation in breast cancer were closely related to the cell cycle,and those down-regulated were significantly enriched in the hormone response function.Study on DNA methylation revealed that breast cancer showed an unique DNA methylation pattern.Further analysis reveals 23 breast cancer genes induced by abnormal DNA methylation.Conclusion DNA methylation can mediate the abnormal expression of breast canc-er genes,and is an important biological marker for early diagnosis and prognosis of breast cancer.
