New progress of the research on the DNA methyltransferases in the pathogenesis of carcinoma
10.3969/j.issn.1002-3070.2014.01.016
- VernacularTitle:DNA 甲基转移酶在肿瘤发病机制中的研究进展
- Author:
Shulei ZHAO
;
Jing WANG
- Publication Type:Journal Article
- Keywords:
Carcinoma;
DNA methylation;
DNA methyltransferase
- From:
Practical Oncology Journal
2014;(1):75-80
- CountryChina
- Language:Chinese
-
Abstract:
DNA methylation is the main profile of epigenetics .DNA methyltransferases ( DNMTs) is the main regulatory enzyme during DNA methylation .The activation of DNMTs ,the hypermethylation and low expres-sion of some tumor suppressor genes are involved in the carcinogenesis and development of various human canc -ers,which is a biomarker of poor prognosis .Both of the polymorphism of DNA methyltransferases ( DNMT3b) and tobacco smoking are risk factors of tumorgenesis .The targeted therapy of DNMTs is very popular due to its low cy-totoxity.This review will focus on new progress of the research on DNMTs in pathogenesis of carcinoma .
