The research progression on SPOCK1 and tumor
10.11904/j.issn.1002-3070.2015.04.021
- VernacularTitle:SPOCK1蛋白结构和功能与肿瘤的研究进展
- Author:
Haonan GUO
;
Shiyun PENG
- Publication Type:Journal Article
- Keywords:
SPOCK1;
Proteoglycan;
Extracellular matrix;
Tumor
- From:
Practical Oncology Journal
2015;(4):380-384
- CountryChina
- Language:Chinese
-
Abstract:
Testicular proteoglycan 1 ( SPOCK1 ) , a kind of extracellular matrix glycoprotein, can inhibit the activity of cathepsin and promotes the combination of low affinity for calcium.SPOCK1 is essential to the de-velopment of mammals.It not only regulates cell,and the interactions between cells and matrix are also related to cell migration and proliferation.Currently,SPOCK1is confirmed that expression can promote the occurrence and development of tumor,suggesting it could be a new anti-tumor target.This article is to review SPOCK1 molecular structure,biological function and its relationship with tumor.
