Research progress of MMP-7 in non-small lung cancer
10.11904/j.issn.1002-3070.2016.01.020
- VernacularTitle:MMP-7在非小细胞肺癌中的研究进展
- Author:
Xi SUN
- Publication Type:Journal Article
- Keywords:
Matrix metalloproteinases7;
Lung cancer;
Invasion;
Metastasis
- From:
Practical Oncology Journal
2016;30(1):93-96
- CountryChina
- Language:Chinese
-
Abstract:
Lung cancer is one of the most common malignant tumors in the world.Non-small lung canc-er( NSCLC) accounts for approximately 85%,but its pathogenesis has not been elucidated.As a family of soluble enzymes,matrix metalloproteinases(MMPs)can degrade the constituents of the extracellular matrix(ECM)and the basement-membrane,members share common structural features and are responsible for the relative specific sub-strates.Some researches show that the matrix metalloproteinases 7(MMP-7)involve in the invasion and metasta-sis of NSCLC,the expression of MMP-7 in the tissue of NSCLC is significcantly higher than that in adjacent tis-sues,and the MMP-7 plays important roles in prognosis evaluation of NSCLC patients.Therefore this paper sum-marize the domain structure,function,regulation and research in NSCLC about MMP-7.
