Research progress of decorin gene in oncology
10.11904/j.issn.1002-3070.2016.01.009
- VernacularTitle:核心蛋白聚糖基因在肿瘤学中的研究进展
- Author:
Li WANG
- Publication Type:Journal Article
- Keywords:
Decorin;
Gene;
Tumor;
Progress
- From:
Practical Oncology Journal
2016;30(1):44-47
- CountryChina
- Language:Chinese
-
Abstract:
Decorin( DCN) is one of the leucine-rich proteoglycan family of small molecules.It is recog-nized as a tumor suppressor gene.DCN can inhibit tumor cell proliferation and metastasis by binding and inactiva-tion of transforming growth factor beta( TGF-β) and inhibiting the expression of vascular endothelial growth fac-tor or by activating the signaling pathway that promotes cell proliferation by EGFR/MAPK/p21.it plays an impor-tant effect on tumor development,angiogenesis and metastasis.DCN is expressed in various malignant tumors,By up or down regulation,DCN can exert its anti tumor activity,as well as reducing or delaying the occurrence and development of many kinds of malignant tumor.DCN gene may be a potential target for the treatment of many kinds of malignant tumors.
