Progress in research on relationship between microRNA-7 and lung cancer
10.11904/j.issn.1002-3070.2016.01.010
- VernacularTitle:MicroRNA-7与肺癌关系的研究进展
- Author:
Yanyan CHEN
;
Jiao LIAO
- Publication Type:Journal Article
- Keywords:
MicroRNAs;
miR-7;
Lung cancer
- From:
Practical Oncology Journal
2016;30(1):48-52
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNA-7(miR-7)was firstly found in Drosophila melanogaster,which participated in the formation of Drosophila wings,eggs and so on.In human being miR-7 is not only involved in cell prolifera-tion and differentiation,but also plays an important role in the development of tumor,especially in lung cancer. Most studies report that miR-7 is low expression in lung cancer with poor prognosis.Improving the expression of miR-7 can inhibit tumor growth.MiR-7 can regulate the expression of BCL-2,EGFR negatively,meanwhile it can regulate the sensitivity of tumor cells to radiotherapy chemotherapy and targeted therapy.Therefore,as a tumor suppressor,miR-7 is expected to become a new target for treatment of lung cancer.
