Advances in cancer therapy by targeting vasculogenic mimicry
10.11904/j.issn.1002-3070.2015.04.016
- VernacularTitle:靶向血管生成拟态治疗肿瘤的研究进展
- Author:
Furong LI
;
Xianshuo CHENG
;
Yunfeng LI
- Publication Type:Journal Article
- Keywords:
Vasculogenic mimicry;
Cancer therapy;
Antiangiogenic
- From:
Practical Oncology Journal
2015;(4):359-363
- CountryChina
- Language:Chinese
-
Abstract:
Tumor microvessel including two modes,as one is classic vascular structures surrounded with vascular endothelial cells and the other is vasculogenic mimicry( VM) surrounded with cancer cells.Recent studies suggested that anti-angiogenic drugs can inhibit classic microvessel structure significantly, but can not inhibit VM formation and even promote VM formation further more.This is one of the reasons affecting its clinical effica-cy.However,basic research has shown that traditional chinese medicine,gene therapy and drugs which is targeting for VM formation have an unique advantage in anti-VM.In this review, we summarize the progress of cancer therapy on targeting vasculogenic mimicry,and provide a basic for the development of new drugs for cancer thera-py through targeting both angiogenesis and VM formation.
