Prophylaxis for Hepatitis B Core Antibody-Positive Donors after Liver Transplantation.
10.4285/jkstn.2010.24.2.73
- Author:
Hee Yeon KIM
1
;
Jong Young CHOI
Author Information
1. Department of Internal Medicine, The Catholic University of Korea College of Medicine, Center for Liver Transplantation, Seoul St. Mary's Hospital, Seoul, Korea. jychoi@catholic.ac.kr
- Publication Type:Review
- Keywords:
Hepatitis B core antibody positive donor;
Prophylaxis;
De novo hepatitis B;
Liver transplantation
- MeSH:
Hepatitis;
Hepatitis B;
Humans;
Korea;
Liver;
Liver Transplantation;
Tissue Donors;
Transplants
- From:The Journal of the Korean Society for Transplantation
2010;24(2):73-79
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
The growing shortage of organs for orthotopic liver transplantation (OLT) has led to an expanded donor pool with the use of marginal grafts. Recipients who receive liver grafts from HBsAg-negative, anti-HBc positive donors have an increased risk of developing de novo hepatitis B infection. This review covers several issues in liver transplantation using hepatitis B core antibody-positive donors: (1) the mechanism of de novo hepatitis B infection, (2) high risk groups, (3) prophylactic regimens and (4) clinical significance and a proposal for patients in Korea.
