Research progress on molecular mechanism of sporadic colorectal cancer

VernacularTitle:散发性结直肠癌的分子机制研究进展
Author: Yingying FENG
Publication Type:Journal Article
Keywords: Colorectal cancer; The chromosomal instability; Microsatellite instability; Cytosine-phospho-guanine island methylator phenotype; DNA methylation
From: Practical Oncology Journal 2015;29(5):471-475
CountryChina
Language:Chinese
Abstract: Colorectal cancer( CRC) is one of the most common tumor,which has complicated pathogene-sis.it is estimated that the vast majority of CRCs is non-hereditarysporadic cancerswith no apparent evidence of an inherited component.Sporadic CRC results from the cumulative effects of multiple genetic and epigenetic al-terations caused by somatic mutations, which may be the indirect result of several environmental factors them-selves.There are at least 3 major genetic alternations that lead to colorectal carcinogenesis:(1)The chromosomal instability(CIN)pathway;(2)The microsatellite instability(MSI)pathway;(3)The cytosine-phospho-guanine ( CpG) island methylator phenotype( CIMP) pathway,while DNA methylation,modifications in histone proteins and microRNAs( miRNAs) are analyzed in the field of epigenetic alterations.This review summarizes the newest bio-molecular progression involved in CRC pathogenesis,for the purpose of improving strategy for prevention,surveil-lance,early diagnosis and therapy.