The dynamic research of Th17 cells, NK cells and IFN-γ, IL-17 in perioperative patients with lung cancer
10.3969/j.issn.1002-3070.2013.06.009
- VernacularTitle:围术期肺癌患者 Th17细胞、NK 细胞及IFN -γ、IL -17的动态研究
- Author:
Dexin MENG
;
Huaxing WU
;
Jiasheng HAN
;
Aijun XU
;
Rui MENG
- Publication Type:Journal Article
- Keywords:
Lung cancer;
Th17;
IL-17;
NK;
IFN-γ
- From:Practical Oncology Journal
2013;(6):523-527
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the dynamic changes of Th 17 ,NK and IFN-γ,IL-17 in periop-erative patients with lung cancer .Methods Twenty cases of patients with lung cancer surgery were chosen ran-domly.Ten cases of healthy were used as control .We detected the express of Th17,NK,IFN-γand IL-17.Re-sults Compared with the control group , the levels of Th17 and IL -17 increased significantly in lung cancer group(P<0.05);Compared with the pre -operation,the levels of Th17 and IL-17 increased significantly after 1st day of lung cancer surgery .However,the levels of NK and IFN -γdecreased significantly .The expression of Th17 and IL-17 decreased obviously after 5 days of lung cancer surgery .However,the levels of IFN -γin-creased significantly(P<0.05).The correlation analysis showed that there was a positive correlation between Th17 and IL-17A,NK and IFN-γof peripheral blood with lung cancer patients (P<0.01),negative correla-tion between Th17 and NK,IFN-γof peripheral blood with lung cancer patients (P<0.05).Conclusion The immune suppress before activating at perioperative ,it is important for lung cancer patients to detect the levels of Th17,IL-17,NK,IFN-γin peripheral blood .
