Functional characteristic research progress of DCLK1 as a potential biomarker in cancer stem cells for gastrointestinal onalignancies

VernacularTitle:肿瘤干细胞潜在标志物 DCLK1 在消化道恶性肿瘤中的研究进展
Author: Fulian LV ; Xiang GAO
Publication Type:Journal Article
Keywords: DCLK1; Neoplastic stem cells; Gastrointestinal tumor; Targeted therapy; Prognosis
From: Practical Oncology Journal 2015;29(5):458-461
CountryChina
Language:Chinese
Abstract: The discovery and application of cancer stem cell markers have very important significance on tumor treatment and prevention.DCLK1 is discovered only in the cancer stem cell marker but not nomal stem cells for the first time.Some studies have shown that DCLK1 expression was detectded in gastrointestinal cancer,esoph-ageal cancer,bile duct carcinoma and glioma.The expression of DCLK1 in tumor is closely related to tumor devel-opment,progression,and recurrenceand migration.Although DCLK1 remain to be known as cancer stem cell mark-er,it provides a new developing prospectives for tumor targeting specific treatment.