Effect of ginsenoside(Rg3)combined with delaying tamoxifen resistance in breast cancer

VernacularTitle:人参皂甙延缓乳腺癌三苯氧胺耐药的研究
Author: Ying PIAO ; Shuo LI ; Qingyuan ZHANG ; Wenhui ZHAO
Publication Type:Journal Article
Keywords: Ginsenosides; Tamoxifen; Endocrine resistance
From: Practical Oncology Journal 2013;(6):481-484
CountryChina
Language:Chinese
Abstract: Objective To evaluate the effect and the best concentration of Rg 3 combined with delaying tamoxifen resistance in breast cancer .Methods The tamoxifen-resistant(TAM-R)cell line with TAM was es-tablished.TAM-R cell line and WT -MCF-7 cell line were cultured in TAM at different concentrations and then detected the growth of cells .WT-MCF-7 cell line was cultured medium in TAM which contained Rg 3 at different levels .The growing situation of cells was detected with MTT method .Results Compared with wild -type WT-MCF-7 cells,TAM-R showed higher curves when they were both at TAM treatment .Rg3 could be associated with delaying the emergency of tamoxifen resistance and the best concentration was 1 ×10 -8 mol/L and 5 ×10 -8 mol/L.Conclusion It might be useful to reduce the tamoxifen resistance incidence by clinically com-bined Rg3 with TAM treatment .