Effect of ginsenoside(Rg3)combined with delaying tamoxifen resistance in breast cancer
10.3969/j.issn.1002-3070.2013.06.001
- VernacularTitle:人参皂甙延缓乳腺癌三苯氧胺耐药的研究
- Author:
Ying PIAO
;
Shuo LI
;
Qingyuan ZHANG
;
Wenhui ZHAO
- Publication Type:Journal Article
- Keywords:
Ginsenosides;
Tamoxifen;
Endocrine resistance
- From:Practical Oncology Journal
2013;(6):481-484
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect and the best concentration of Rg 3 combined with delaying tamoxifen resistance in breast cancer .Methods The tamoxifen-resistant(TAM-R)cell line with TAM was es-tablished.TAM-R cell line and WT -MCF-7 cell line were cultured in TAM at different concentrations and then detected the growth of cells .WT-MCF-7 cell line was cultured medium in TAM which contained Rg 3 at different levels .The growing situation of cells was detected with MTT method .Results Compared with wild -type WT-MCF-7 cells,TAM-R showed higher curves when they were both at TAM treatment .Rg3 could be associated with delaying the emergency of tamoxifen resistance and the best concentration was 1 ×10 -8 mol/L and 5 ×10 -8 mol/L.Conclusion It might be useful to reduce the tamoxifen resistance incidence by clinically com-bined Rg3 with TAM treatment .
