Preliminary observation of arsenic trioxide inhibitory effect on salivary duct carcinoma
10.3969/j.issn.1002-3070.2013.06.011
- VernacularTitle:三氧化二砷对涎腺导管癌抑制作用的初步观察
- Author:
Zhiyong LYU
;
Taihe WANG
;
Guangzhi ZHU
;
Chunyan YANG
- Publication Type:Journal Article
- Keywords:
Arsenic trioxide;
Salivary duct carcinoma;
Apoptosis
- From:
Practical Oncology Journal
2013;(6):534-538
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the inhibitory effects of arsenic trioxide on salivary duct carcinoma cell colony and to explore a new approach to treat salivary duct carcinoma .Methods Human salivary duct carci-noma cancer cells were established .The effects of different concentrations (0.5、1、2、4μmol/L)and time(48,96 H) of arsenic trioxid on salivary duct carcinoma cell colony and the changes of the cell colony were observed with MTT assay and microscopic cell analysis .Results Human salivary duct carcinoma were significantly inhibited by Different concentrations of arsenic trioxide at different times points , and the relationship between the doses and time points are dependent ,cell atypia disappearing apoptosis appears apoptotic bodies .Conclusion Arsenic tri-oxide can significantly inhibit proliferation ,induce differentiation and promote apoptosis in the salivary duct carci-noma cells .
