A Case of Erythema Nodosum-like Eruptions as a Manifestationof Azathioprine Hypersensitivity.
- Author:
Chul HWANG
1
;
Eun Kyoung JEON
;
Ah Young CHO
;
Sun Hyae JANG
;
Young Joon SEO
;
Jang Kyu PARK
;
Jeung Hoon LEE
Author Information
1. Department of Dermatology, College of Medicine, Chungnam National University, Daejeon, Korea. jhoon@cnu.ac.kr
- Publication Type:Case Report
- Keywords:
Azathioprine hypersensitivity;
Erythema nodosum
- MeSH:
Aged;
Arthritis, Rheumatoid;
Azathioprine;
Bone Marrow;
Cicatrix;
Depression;
Erythema;
Erythema Nodosum;
Female;
Fever;
Humans;
Hypersensitivity;
Hypotension;
Inflammatory Bowel Diseases;
Lower Extremity;
Myasthenia Gravis;
Nausea;
Rejection (Psychology);
Vasculitis;
Vomiting
- From:Korean Journal of Dermatology
2008;46(3):394-396
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Azathioprine is an immunosuppressant that has been widely used in the prevention of organ post-transplantation rejection, rheumatoid arthritis, inflammatory bowel disease and myasthenia gravis. The adverse effects reported with this drug have been classified as early events that include fever, hypotension, vasculitis and erythema nodosum-like eruptions or as late events that include bone marrow depression, nausea and vomiting. Although erythema nodosum-like eruptions could be useful for recognition of azathioprine hypersensitivity, this eruption has not yet been reported in Korean dermatological literature. We report, herein, a 68-year-old female with myasthenia gravis, who presented with tender, erythema nodosum-like eruptions on both upper and lower extremities 14 days after the first administration of azathioprine. Her symptoms improved 2 days after discontinuation of azathioprine and healed with no scarring change.
