The research about the correlation of colorectal adenocarcinoma gene fbxl 20 and E-cadherin
10.3969/j.issn.1002-3070.2013.06.007
- VernacularTitle:结直肠腺癌发病基因fbxl20和E-cadherin的相关性研究
- Author:
Xiaohua ZHU
;
Shishan DENG
;
Xingguo XIE
;
Shiquan XU
;
Maocheng RAN
;
Shaoli XIE
;
Jianjun ZHU
- Publication Type:Journal Article
- Keywords:
fbxl 20;
E-cadherin;
Colorectal adenocarcinoma;
Correlation analysis
- From:Practical Oncology Journal
2013;(6):509-515
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the relationship between the fbxl 20 gene、E-cadherin gene and the clinocopathologic features ,respectively , and the correlation about the fbxl 20 and the set gene .Methods The mRNA expression level of fbxl 20 and E-cadherin gene in 50 pairs of human colorectal adenocarcinoma tissues and matched normal tissues were detected by RT -PCR.Results The mRNA expression level of fbxl 20 gene in tumor tissues were significantly increased than that in normal tissues (0.479 ±0.141 vs.0.296 ±0.121,P=0.001),while the E-cadherin were decreased (0.440 ±0.026 vs.0.741 ±0.059,P=0.000).There was no found on the correlation between the mRNA expression level of fbxl 20 and the E-cadherin gene in the 50 tumor tissues(r=-0.165,P=0.251).However,the E-cadherin expressed level was negatively correlated with the fbxl 20 expressed level in the lower differentiation degree、in the high differentiation degree and the Duke′s D tumor tissues(r=-0.600,P=0.008;r=-0.784,P=0.017;r=-0.643,P=0.032).Conclusions The decreased mRNA expression level of E -cadherin in tumor tissues are largely due to the increased fbxl 20 gene expressed level ,which is related with the high mobility and invasion ability of the advanced tumor .
