The effects of chemotherapy on the peripheral blood lymphocyte sub-cluster in patients with ovarian cancer
10.3969/j.issn.1002-3070.2013.06.012
- VernacularTitle:化疗对卵巢癌患者外周血淋巴细胞亚群的影响
- Author:
Jing WANG
- Publication Type:Journal Article
- Keywords:
Ovarian cancer;
Chemotherapy;
Lymphocyte sub-cluster
- From:
Practical Oncology Journal
2013;(6):539-542
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of chemotherapy on the peripheral blood lymphocyte sub-cluster in patients with ovarian cancer .Methods Sixty-two patients with ovarian cancer who accepted chemo-therapy from Jan 2007 to Mar 2013 in our hospital were collected .Sixty healthy women in our hospital were used as control.The expressions of CD3,CD4,CD8 and CD25 in peripheral blood lymphocyte of ovarian cancer patients before,one week and one month after chemotherapy and healthy women were detected and analyzed .Results The ratio of CD3 +and CD4 +T cells and CD4 +/CD8 +in patients with ovarian cancer were significantly lower than those in healthy .Whereas the ratio of CD4 +CD25 +T cells in patients with ovarian cancer was significantly higher than that in healthy women .No significant differences were observed in ovarian cancer patients with differ-ent clinical stage .There were no significant changes that observed one week after chemotherapy in patients with o -varian cancer .These indexes improved notably one month after chemotherapy .These indexes in effective group one month after chemotherapy were significantly better than those in inefficient group .Conclusion The ratio of pe-ripheral blood lymphocyte sub -cluster in patients with ovarian cancer was imbalance .Dynamic monitoring the changes could guide the therapy and judge the curative effect and prognosis .
