Research progress on focal adhesion kinase in malignant tumors
10.11904/j.issn.1002-3070.2016.02.015
- VernacularTitle:FAK 在恶性肿瘤中的研究进展
- Author:
Meina ZHAO
;
Gongyan CHEN
- Publication Type:Journal Article
- Keywords:
Focal adhesion kinase;
Cancer;
Signal pathway
- From:
Practical Oncology Journal
2016;30(2):162-166
- CountryChina
- Language:Chinese
-
Abstract:
Focal adhesion kinase( FAK) ,a cytoplasmic non-receptor protein tyrosine kinase,serves as both a molecular scaffold and a mediator participating in multiple signal transduction pathways.FAK is involved in tumor cell survival,proliferation,migration and metastasis.Recent studies have shown that FAK is expressed in many tumor cells.Currently,FAK has been regarded as a potential target for cancer therapy.This review is to summarize the relationship between FAK and tumor progression.
