Study progresses of tumor immunosuppressive microenvironment in tumor immunotherapy
10.11904/j.issn.1002-3070.2016.02.016
- VernacularTitle:肿瘤免疫抑制微环境对肿瘤免疫治疗作用的研究进展
- Author:
Rui ZHANG
;
Zhiyu WANG
;
Xiaoting WEN
;
Hui ZHAO
- Publication Type:Journal Article
- Keywords:
Immunosuppressive microenvironment;
Immunotherapy;
Chimeric antigen receptor T cell;
Programmed death 1;
Programmed death 1 ligand
- From:
Practical Oncology Journal
2016;30(2):167-171
- CountryChina
- Language:Chinese
-
Abstract:
Immunosuppressive tumor microenvironment is a part of the tumor microenvironment that plays an immunosuppressive function.It consists of suppressor cells and inhibitory cytokines.In recent years,be-cause of its important role in tumor immunity,CAR-T and PD-1/PD-L1 signal pathway has become a hot top-ic of immunotherapy, which can suppress immune through different mechanisms to promote tumor progression. Therefore,taking more effective anti-tumor therapies against the above mechanisms is possible to rescue the pro-gress of tumor.In this article,the influence of immunosuppression microenvironment in CAR-T cell therapy and PD-1/PD-L1 signaling pathway in the anti-tumor process is reviewed.
