LncRNAs and drug resistance in tumors
10.11904/j.issn.1002-3070.2016.02.012
- VernacularTitle:长链非编码 RNA 与肿瘤耐药性的研究进展
- Author:
Shuqi CHI
;
Hongbo WANG
- Publication Type:Journal Article
- Keywords:
LncRNAs;
Tumor multidrug resistance;
Gene expression regulation
- From:
Practical Oncology Journal
2016;30(2):150-153
- CountryChina
- Language:Chinese
-
Abstract:
Chemotherapy is one of the primary treatments for cancer patients,while tumor multidrug re-sistance( MDR) represents a major obstacle in the treatments of patients,limiting the efficacy of chemotherapy.To date,the mechanism of drug resistance has not been fully elucidated.lncRNAs are a family of long noncoding RNAs that regulate gene expression by epigenetic modification,transcription and post transcriptional processing. Recent studies have showed that the aberrant regulation of target genes by lncRNAs may be involved in the acqui-sition of tumor MDR.Therefore,targeting lncRNAs may be an attractive strategy for improving the chemosentivity and reversing chemotherapeutic resistance.This paper reviews the relationship between lncRNAs and tumor drug resistance as well as the underlying possible mechanism.
