The clinical significance of CD46 expression after neoadjuvant chemotherapy for the prognosis of ad-avnced breast cancer patients
10.3969/j.issn.1002-3070.2014.02.006
- VernacularTitle:新辅助化疗对进展期乳腺癌患者 CD46表达影响及临床预后预测意义的研究
- Author:
Jie LI
- Publication Type:Journal Article
- Keywords:
Advanced breast cancer;
Neoadjuvant chemotherapy;
CD46;
Prognosis
- From:
Practical Oncology Journal
2014;(2):123-128
- CountryChina
- Language:Chinese
-
Abstract:
Objective The purpose of this study is to investigate CD 46 expression in advanced invasive breast cancer and in normal breast tissues , and to analyze the correlation between CD 4 expression and effect of neoadjuvant chemotherapy ,exploring its clinical significance for the prognostic value of neoadjuvant chemotherapy in breast cancer .Methods Immunohistochemistry was employed to detect CD 46 expression of tissue samples from 60 patients with invasive breast cancer and 30 normal breasts .We further analyzed the relationship between effect of neoadjuvant chemotherapy and CD 46 expression ,and the prognostic significance for the survival .Rseults CD46-positive rate in breast cancer was apparently higher than that in normal breast tissues (81.67% vs. 46.67%,P<0.05).After neoadjuvant chemotherapy,the CD46 expression was significantly decreased (P <0 .05).There was a negative correlation between CD 46 expression and efficacy of chemotherapy ( P<0.05). CD46 expression in breast cancer could be affected in cancer invasion ,lymph node metastasis(P<0.05).Con-clusion CD46 expression in breast cancer patients is higher than that in healthy people ,and was negatively cor-related with efficacy of adjuvant chemotherapy .The increasing rate of CD 46 positive expression has predictive val-ue for the poor prognosis of patients .
