Reviews on association between the inhibitory costimulatory molecules B7 -H4 and female malignant tumor
10.11904/j.issn.1002-3070.2015.01.011
- VernacularTitle:抑制性协同刺激分子 B7-H4在女性常见恶性肿瘤中的研究进展
- Author:
Jinghua WAN
;
Zhenkun FU
- Publication Type:Journal Article
- Keywords:
B7-H4;
Breast cancer;
Ovarian cancer;
Uterine neoplasm
- From:
Practical Oncology Journal
2015;(1):53-56
- CountryChina
- Language:Chinese
-
Abstract:
The new costimulatory molecule B7-H4,also called V-set domain containing T cell activa-tion inhibitor 1(VTCN-1),is a member of the B7 family.B7-H4 can negatively regulate the immune response of T lymphocytes through inhibiting their proliferation and cytokine production .The expression of B7-H4 plays an important role in initiation ,progression and regression of malignant tumors ,including female malignant tumor , such as breast cancer ,ovarian cancer and uterine neoplasm .The association between the female tumors and B 7-H4 causes great concern in recent years .In this review,the function of B7-H4 in female tumor research and the potential target of B7-H4 in the diagnosis and treatment of female tumor are summarized .
