The research progression on the relationship between TRPS1 and tumors
10.11904/j.issn.1002-3070.2015.01.017
- VernacularTitle:毛发鼻指(趾)综合征-1基因与肿瘤关系的研究进展
- Author:
Jia ZHAO
;
Yulin SONG
;
Yuxia ZHANG
;
Binzhou SUN
;
Jing WANG
- Publication Type:Journal Article
- Keywords:
TRPS1;
Tumor;
Abnormal expression;
GATA
- From:
Practical Oncology Journal
2015;(1):78-81
- CountryChina
- Language:Chinese
-
Abstract:
Tricho-rhinophalangeal syndrome -1 gene(TRPS1),a new GATA family member,is highly prevalent in many tissues .It plays an important role in the regulation of cell proliferation and tissue development . The genetic missing of TRPS1 may lead to Tricho-rhinophalangeal syndrome .In recent years,studies have dem-onstrated that TRPS1 abnormal expression exists in a variety of tumors , and is associated with carcinogenesis , lymph node metastasis,pathological grading and clinical staging .Therefore,TRPS1 is considered as a potential tumor suppressor gene ,its overexpression may be one of mechanisms for carcinogenesis and progression of cancer . This review focuses on the role of TRPS 1 gene in carcinogenesis and progression of carcinoma ,and further to pro-vide a new biomarker for predicting cancer prognosis and therapy .
