Correlated research between the expressions of C-met and COX-2 in papillary thyroid cancer
10.11904/j.issn.1002-3070.2014.05.003
- VernacularTitle:C －met 和 COX －2在甲状腺乳头状癌中的表达及其相关性研究
- Author:
Ying SUN
;
Yunxiao TIAN
;
Shuanghai WANG
;
Jing WANG
;
Xiaoming SONG
;
Xiaohui ZHANG
- Publication Type:Journal Article
- Keywords:
Thyroid tumor;
Papillary cancer;
C-met;
COX-2;
Immunohistochemistry
- From:
Practical Oncology Journal
2014;(5):396-400
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the expressions of C -met and COX -2 in thyroid papillary cancer ( TPC) and to analyze the relationship between their expressions and clinicopathological features .Methods S-P immunocytochemical technique was used to examine the expressions of C -met and COX-2 in 96 cases of TPC and 46 cases of benign tissues ,and their relationship with clinicopathological features were analyzed .Results The positive rates of C -met and COX -2 in 96 cases of TPC were 92.71% and 71.88%,showing obvious differences between TPC and benign tissues (P<0.001).In TPC there is a statistically significant difference of the expression of C-met in older than45 years and less than 45 years of age(P<0.05).Difference of COX-2 expression in TPC was statistically significant in patients with and without lymph node metastasis ( P<0.05 ) . The positive expression of COX -2 was closely related to the expression of C -met(r=0.451,P<0.05).Con-clusion The abnormal expressions of C -met and COX-2 could be important significance in the growth and in-vasion of TPC,and COX-2 might have some relationship with lymph node metastasis .
