The expression of tumor suppressor gene PTEN,PI3K and AKT in lung cancer
10.3969/j.issn.1002-3070.2014.02.005
- VernacularTitle:抑癌基因PTEN、PI3K、AKT在肺癌中的表达及临床意义
- Author:
Guodong MA
- Publication Type:Journal Article
- Keywords:
Tumor suppressor gene;
PTEN;
PI3K;
AKT;
Lung cancer
- From:
Practical Oncology Journal
2014;(2):118-122
- CountryChina
- Language:Chinese
-
Abstract:
Objective The purpose of this study is to discuss the expression and pathological signifi-cance of tumor suppressor genes PTEN ,PI3K and AKT in lung cancer .Methods SP immunohistochemical meth-od was used to detect the expressions of PTEN ,PI3K and AKT in 62 cases of lung cancer tissues and 30 cases of cancer adjacent tissues ,and analyzed the correlation and relationship with clinical pathological features .The aim was to explore their roles in lung cancer mechanism .Results The mRNA expression of PTEN in lung cancer tis-sue was significantly lower than that in cancer adjacent tissue ,whereas,the mRNA expressions of PI3K and AKT were significantly higher than that in cancer adjacent tissue (P<0.05).Positive expression rate of PTEN in lung cancer tissues was 48.39%(30/62),which was significantly lower than that of cancer adjacent tissue .The posi-tive expression rate of PI3K and AKT in lung cancer tissue were 79.03%(49/62)and 70.97%(44/62),which was significantly higher than that in cancer adjacent tissue (P<0.01).The expressions of PTEN and PI3K were related with the degree of differentiation ,TNM stage,lymph node metastasis of lung cancer and pathological types . AKT expression was related with the TNM stage ,lymph node metastasis and pathological types of lung cancer ( P<0.05).PI3K and AKT expression were positively correlated (P<0.05),PI3K and PTEN expression were negatively correlated(P<0.05),AKT and PTEN expression were negatively correlated (P<0.05).Conclusion The deceased expression of PTEN tumor suppressor gene in lung cancer and increased expression of PI 3K/AKT,prompt the PTEN and PI3K,and AKT may promote the occurrence ,development and metastasis of lung cancer,and PI3K/AKT signal pathways play an important role in the process ,the gene targeted therapy of lung cancer may provide a new direction .
