The progression on tyrosine kinase receptor EphA7 in tumor

VernacularTitle:酪氨酸激酶受体 EphA7在恶性肿瘤中的研究进展
Author: Fengrui ZHOU ; Gongyan CHEN
Publication Type:Journal Article
Keywords: Tyrosine kinase receptor; EphA7; Tumor
From: Practical Oncology Journal 2015;(1):61-64
CountryChina
Language:Chinese
Abstract: EphA7 is one of the most important members of the Eph family .It is a key regulatory factor of cell adhesion and repulsion ,it also contributes to establish men ,maintain ance and tissue remodeling in cell mor-phology .In recent years ,its function in tumors has been revealed gradually .It plays a variety of roles in different tumors.The overexpression of EphA7 can be detected in acute leukemia ,glioblastomamultiforme,lung cancer and hepatic carcinoma ,which suggests EphA 7 may be involved in the development of these tumors .While in colon cancer,prostate cancer,follicular lymphoma and gastric cancer ,a significant reduction of EphA7 expression with promoter hypermethylation is discovered ,which suggests EphA 7 play a tumor suppressor role in these tumors .E-ven though the function of EphA 7 is still under exploration , EphA7 and tumor development are inextricably linked,it may have roles in the pathogenesis and development of these carcinomas .