Advances in AEG-1 mediated drug resistance
10.11904/j.issn.1002-3070.2014.05.015
- VernacularTitle:星形细胞上调基因1（AEG －1）介导肿瘤耐药的研究进展
- Author:
Kexin CHEN
;
Chen LI
;
Yu QIN
;
Guodong YAO
;
Jingshu GENG
- Publication Type:Journal Article
- Keywords:
Astrosyte elevated gene 1;
Drug resistance;
Multidrug resistance gene
- From:
Practical Oncology Journal
2014;(5):447-450
- CountryChina
- Language:Chinese
-
Abstract:
It has been demonstrated that astrocyte elevated gene 1 ( AEG-1 ) can promote tumor initia-tion and progression .Over expression of AEG -1 is correlated with tumor angiogenesis ,metastasis and chemother-apy resistance of tumor cells of different origins .The present article is a review on the mechanism of AEG -1 me-diated drug resistance .Studies have shown that AEG -1 participates in carcinogenesis through Ha -ras,myc,NF-κB and PI3K/Akt signalling pathways .AEG-1 can also promote autophagy through activating AMP Kinase . Other researchers demonstrate that AEG -1 promotes MDR1 protein translation by up-regulating MDR1 mRNA expression ,and thus increases polyribosome .It is testified that AEG-1 can influence drug susceptibility and ex-pression of MDR gene as a RNA binding protein .Multiple functions of AEG -1 in drug resistance in multiple cancers demonstrate that AEG -1 can be used as a novel target for antitumor drugs .
