Expression and diagnostic value of CK19,HBME-1 and MIB-1 between hyalinizing trabecular tumor and thyroid papillary carcinoma
10.11904/j.issn.1002-3070.2014.04.008
- VernacularTitle:CK19，HBME -1和 MIB -1在甲状腺透明变梁状肿瘤与甲状腺乳头状癌中的表达情况以及鉴别诊断价值
- Author:
Yingwei WANG
;
Hongda WANG
;
Hong ZHU
- Publication Type:Journal Article
- Keywords:
Hyalinizing trabecular tumor;
Papillary carcinoma;
CK19;
HBME-1;
Immunohistochemistry
- From:
Practical Oncology Journal
2014;(4):326-330
- CountryChina
- Language:Chinese
-
Abstract:
Objective Hyalinizing trabecular tumor ( HTT) is often mistaken as thyroid papillary carcino-ma( TPC) ,which shares some morphological features with TPC .The aim of this study is to investigate HTT and TPC with immunohistochemical methods .Methods we detected the expression of the three Immunohistochemical index((CK19,HBME-1,MIB-1)in thirteen cases HTT and twenty cases TPC.Results In HTT samples, CK19:three of the thirteen were positive and focal positivity (1+);HBME-1:None of the thirteen samples was stained.MIB-1:ten in thirteen cases were stained in nucleus .In TPC samples,CK19:all of the twenty samples were intensely stained;HBME-1:nineteen of twenty samples were intensely stained;MIB-1:all of the twenty samples were stained in nucleus .The sensitivity and specific degrees of CK 19 and HBME-1 combination to diag-nosis HTT and TPC were 90.0%and 69.2%.Conclusion Our research could provide potent aid to differential diagnosis of HTT and TPC .The combination of CK19 and HBME-1 are adequate to identify HTT and TPC .
