A Case of Acral Erythema Induced by Etoposide.
- Author:
Eun Kyoung JEON
1
;
Yoo Jin KIM
;
Young LEE
;
Young Joon SEO
;
Jang Kyu PARK
;
Jeung Hoon LEE
Author Information
1. Department of Dermatology, School of Medicine, Chungnam National University, Daejeon, Korea. jhoon@cnu.ac.kr
- Publication Type:Case Report
- Keywords:
Acral erythema;
Etoposide
- MeSH:
6-Mercaptopurine;
Adolescent;
Cell Division;
Child;
Cytarabine;
Doxorubicin;
Erythema;
Etoposide;
Fluorouracil;
Hand-Foot Syndrome;
Hematologic Neoplasms;
Humans;
Methotrexate;
Podophyllotoxin;
Proteins
- From:Korean Journal of Dermatology
2008;46(3):418-420
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Etoposide is a semi-synthetic podophyllotoxin that binds to microtubular proteins to inhibit cell division. It has been used extensively in the treatment of both solid and hematologic malignancies. Chemotherapy-induced acral erythema is a distinctive syndrome of painful, symmetric, well-defined swelling and erythema of the palms and soles seen in patients receiving high-dose chemotherapy. It occurs most commonly with fluorouracil, doxorubicin, and especially cytosine arabinoside. Although etoposide, mercaptopurine and methotrexate have also been implicated. Here we report a case of acral erythema induced by etoposide in a 15-year-old child with neuroblastoma.
