The differential expressions of miR-135b,miR-141 in colorectal carcinoma
10.11904/j.issn.1002-3070.2014.05.010
- VernacularTitle:结肠癌中 miR －135 b、miR －141的检测意义
- Author:
Qingyu WU
;
Keke CHEN
;
Long GAO
;
Wanlong LIN
;
Xiaoyuan GU
;
Tao LI
;
Xiaoming MA
;
Wei ZHANG
;
Meiling LIU
- Publication Type:Journal Article
- Keywords:
miR-135 b;
miR-141;
Colorectal carcinoma
- From:Practical Oncology Journal
2014;(5):430-434
- CountryChina
- Language:Chinese
-
Abstract:
Objective Our retrospective study is aimed to analyze the correlative clinical features of be-tween expressions of miR -135b and miR-141 in colorectal cancer.Methods Clinical data and specimens of patients with colorectal carcinoma at our hospital from 2013 to 2014 were retrospectively collected .The expres-sions of miR-135 b and miR-141 between colon cancer and matched normal colonic tissues were compared .The correlation between the expressions of miR -135 b and miR-141 in colorectal carcinoma and the clinical charac-teristics were discussed .Results A total of 42 patients was retrospective analyzed .The expressions of miR -135b,miR-141 in the colon cancer tissues were obviously higher than that in the normal colonic tissues .The differences of the expression of miR -141 in the colon cancer tissues of different Dukes stages ,degree of differen-tiation,lymph node metastasis and infiltration depth were all significant .The expressions of miR -135 b and miR-141 displayed a positive linear correlation .Conclusion The expressions of miR-135b,miR-141 in colorec-tal cancer are significantly increased ,and the expressions display a remarkable correlation with the Dukes stages , degree of differentiation ,lymph node metastasis and infiltration depth of tumor .The expressions of miR-135 b and miR-141 demonstrate a positive correlation .
