MLN64 gene and its research advancement in the field of carcinogenesis and progression of breast cancer
10.11904/j.issn.1002-3070.2014.04.014
- VernacularTitle:MLN64基因及在乳腺癌发生发展中作用的研究进展
- Author:
Wei CAI
;
Hua KANG
- Publication Type:Journal Article
- Keywords:
MLN64;
Gene;
Breast cancer
- From:
Practical Oncology Journal
2014;(4):354-359
- CountryChina
- Language:Chinese
-
Abstract:
The MLN64 gene,which is localized in q12-q21 of the human chromosome 17,encodes a novel transmembrane protein containing 445 amino acids .The C-terminus of MLN64 shares significant homology with the steroidogenic acute regulatory (StAR)protein,while its N-terminal domain exhibits a function of targe-ting the protein to late endosomes .MLN64 is likely to be involved in cholesterol transport and synthesis of steroid hormones.MLN64 gene,coamplified with C -erbB-2,is overexpressed in certain breast carcinomas and exerts an influence on biological characteristics of breast cancer cells .The high levels of MLN 64 observed in some breast carcinomas could contribute to the growth and progression of these tumors through increased intratumoral steroido -genesis,and is considered as a predictive factor of breast cancer prognosis .
