The role of Notch3 in tumorgenesis and progression
10.11904/j.issn.1002-3070.2014.05.016
- VernacularTitle:Notch3在肿瘤发生发展中的作用
- Author:
Jie QIAO
;
Caijie LU
;
Qingyu ZHANG
- Publication Type:Journal Article
- Keywords:
Notch3 receptor;
Tumor;
Mechanism
- From:
Practical Oncology Journal
2014;(5):451-455
- CountryChina
- Language:Chinese
-
Abstract:
Notch signaling pathway is a highly conserved signaling pathway ,and plays an important role in the individual growth and development process in the vertebrate .Many studies have demonstrated Notch 3 re-ceptor expression is aberrant in a variety of tumors .Recent studies show that aberrant Notch 3 mediated signaling pathway is closely related with the progression of diverse types of tumors .Notch3 plays a vital role in apoptosis , proliferation and differentiation of tumor cells .To promote the studies of Notch 3 as a drug development targets ,the molecular mechanisms of abnormal Notch 3 expression and its role on tumorgenesis ,progression and treatment re-sistance are reviewed in this paper .
