The expression and clinical significance among CD44 +/CD24 -,E-cadherin and ivm entin in non-sma ll cell lung canc er
10.11904/j.issn.1002-3070.2014.04.006
- VernacularTitle:CD44＋／CD24-联合 E -cadherin、Vimentin在非小细胞肺癌组织中的表达及临床意义
- Author:
Xueqing GUAN
;
Leiguang YE
;
Yue GAO
;
Xun QIU
;
Lan WANG
;
Di WANG
;
Baogang LIU
- Publication Type:Journal Article
- Keywords:
CD44 +/CD24 -;
EMT;
E-cadherin;
Vimentin;
NSCLC
- From:
Practical Oncology Journal
2014;(4):315-320
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the expression of CD 44 +/CD24 -and E-cadherin and vimentin in non-small cell lung cancer and its clinical prognostic relevance .Methods By immunohistochemistry , detecting , 500 cases of non-small cell lung cancer E -cadherin ,Vimentin and CD44 +/CD24 -expressions′correlation ,we analyzed the relationship with non -small cell lung cancer .Results In non-small cell lung cancer , vimentin was related to tissue differentiation,TNM staging(P<0.05);there was relationship between CD44 +/CD24 -and EMT by E-cadherin expression(P <0.05);CD44 +/CD24 -expression was related to lymph node metastasis , differentiation(P<0.05);their expressions were not obviously related to age ,sex,smoking history,clinical patho-logical type .The survival time of CD44 +/CD24 -high expression in NSCLC was significantly shorter than lower expression in NSCLC(P<0.05).Conclusion EMT malignant phenomenon raises cancer stem cells ,which can lead to the development of malignant cells poorly differentiated trends ,they are not an isolated process;important role in the development of EMT and CD 44 +/CD24 -union occurs in non -small cell lung cancer and prognosis with patients ,which provides a potential breakthrough in the treatment of cancer prevention and treatment targets .
